hydrates e.g. The understanding of the physical and chemical properties of different solid forms enables the identification of the most appropriate modification for use in drug development by assessing the risk of form changes under normal and accelerated conditions. There is sometimes a confusion between cocrystals and solvates/hydrates. The main difference between solvate/hydrate and cocrystals is the physical state of the isolated pure components. I can explain the differences in solubility by assuming that the water molecules within the crystal structure of sodium sulfate heptahydrate lower the enthalpy of crystallization, which makes solvation energetically more favorable than the anhydrous salt. hydrates of thiourea (Figuiere et al., 1975; Tomkowiak et al., 2013; Tomkowiak & Katrusiak, 2018) and at pressures above 8 GPa no methane hydrates are formed (Kevenvolden, 1995). Propensity for Solvate/Hydrate Formation U. Griesser, The Importance of Solvates, In: Polymorphism in the Pharmaceutical Industry, R. Hilfiker, ed., Wiley-VCH, Weinheim, 2006, 211-234. Salt form of the drug. Weakly acidic drugs – strong basic salt e.g.barbiturates , sulfonamides. Hydrates are formed from ionic compounds when they exposed … Considering that the synthetic route of STG generates solvates and hydrates , and the dehydration process is an expensive step in industrial scale. If one of the components is liquid and the other is solid, then it is termed as solvates but on the other hand, if both exist in the solid form then they are termed as cocrystals. Exemplary solvates include hydrates, ethanolates, methanolates, isopropanolates and the like. A polymorph screen on a new 1:1 co-crystal of caffeine, C8H10N4O2, with anthranilic acid, C7H7NO2, has revealed a rich diversity of crystal forms (two polymorphs, two hydrates and seven solvates, including two sets of isostructural solvates). Assembly of solvents in the crystal lattice (hydrates, solvates) stoichiometric or non-stoichiometric. Its use is not limited solely to the determination of purity, polymorphs, solvates and hydrates, melting point, and component quantification but also allows the characterization of the surface properties of powders, such as humectants, adsorbents, and surface energy, thus constituting a useful tool in decision making in the case of problems related to the production process. This chapter discusses pseudopolymorphism, and focuses primarily on crystal hydrates. US20130211101A1 US13/781,390 US201313781390A US2013211101A1 US 20130211101 A1 US20130211101 A1 US 20130211101A1 US 201313781390 A US201313781390 A US 201313781390A US 2013211101 A1 US2013211101 A1 US 2013211101A1 Authority US United States Prior art keywords glycopyrrolate tosylate glycopyrrolate tosylate peaks characterize Prior art date 2013-02-28 Solvates and hydrates can be very stable solid forms and may have definite benefits in regard to manufacturing. Hydrates and solvates are thus multicomponent crystalline solid molecular adducts containing both the host molecule (API or excipient) and guest molecule (water (hydrate) or other solvents (solvate)) incorporated in the crystal lattice structure, commonly known as pseudopolymorphic forms. Crystalline solids normally require a significant amount of energy for dissolution due to their highly organized, lattice like structures. Polymorphs, Hydrates and Solvates of a Co-crystal of Caffeine with Anthranilic Acid Nadeesh Madusanka, Mark D. Eddleston, Mihails Arhangelskis and William Jones* Supplementary Material Figure S1 DSC trace (a) and TGA thermogram (b) for Form I of the caffeine:anthranilic acid co-crystal. The solubility tests of these two monohydrates at room temperature (around 23°C) revealed that the difference in aqueous solubility, and thus free energy between these two hydrates, is rather small (110 ± 4 µg/ml and 131 ± 12 µg/ml for hydrates II and I, respectively, ). In addition, the transformation behaviour of solvates during crystallization and storage is often complicated and difficult to understand completely. Polymorphism: Elements can exist in two or more different forms, known as allotropes of that element .eg. This guidance, represents the Food and Drug Administration's (FDA's) current thinking on this topic. A salt with the associated water of crystallization is considered as a hydrate form. 1.2 Crystalline solids: structure and properties 1.2.1 Crystal structure Crystals contain highly ordered arrays of molecules and atoms held together by non-covalent interactions. Hydrates: A wide range of salts form hydrates when dissolved in water. In HG Brittain (ed.) In this review, the fundamental characteristics and trends observed for pharmaceutical hydrates, solvates and amorphous forms are presented, with special emphasis, due to their relative abundance, on pharmaceutical hydrates with single and two-component (i.e. cocrystal) host molecules. 1. Introduction This terminology, Stahly suggests, is descriptive, understandable, and worth keeping. India’s largest k-12 learning app has top-notch teachers from across the nation with excellent teaching skills. A change in solid form is normally evidenced by a discontinuity in the solubility curve, which results from different slope, that is, temperature dependence, of the solubility of the respective forms. What are hydrates? polymorphs, solvates or hydrates. Co-crystals are also generally characterized as hydrates (solvent trapped), solvates (solvent present), and clathrates (molecules trapped) [12]. anhydrous forms of theophyline and ampicillin have higher aqueous solubility than the hydrates. solvate translation in English-French dictionary. These forms have water molecule(s) in the crystalline lattice of the API. hydrates [7] and solvates [8 ]. As moisture is absorbed by a sample, the intermolecular structure and forces within it adapt to accommodate water molecules. The primary difference between solvates and co-crystals is the physical state of the individual components. Part 1. Review of methodology, investigation and prediction of thermodynamic data for sulfur dioxide solvates, MpXq.nSO2, routes to expand the database and forecast of future science and technology. Differences in solid forms often lead to differences in thermodynamic parameters and physicochemical properties for example solubility, dissolution rate, stability and mechanical properties of APIs and excipients. • Drug substance may exist in different solid state forms (polymorphs, solvates, hydrates) • Different physico-chemical properties • Possible effects on dissolution, bioavailability, stability and processability Particle size: Drug substances often milled or micronised … Thus, they are converted to solid forms such as polymorphs, salts, solvates, hydrates, amorphous and co-crystals. The term hydrate is used for crystal structures that contain water molecule (s) in the crystal lattice. Assembly of counter-ions in the crystal lattice proton transfer stoichiometric. Differences between solvates, hydrates and anhydrates/asolvates; Characterisation of solvates and hydrates; Amorphous solids. Material Information Title: Solvates of light metal perchlorates with hydrogen peroxide. This leads to changes in the sample's The present invention relates to 4-[5-Methoxy-6-(2-methyl-6-[l,2,4]triazol-l-yl-pyridin-3- ylamino)-pyrimidin-4-yloxy]-piperidine-l -carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Phase transitions such as polymorph inter-conversion, formation of hydrates, desolvation of solvates, and conversion of the crystalline to amorphous form may occur during various pharmaceutical processes. In addition, the transformation behaviour of solvates during crystallization and storage is often complicated and difficult to understand completely. Thus, the _____ form appears to be more soluble. For example, a working criterion requiring all of the molecular compo-nents to be solids under ambient conditions has been suggested [15,16]. The difference between a crystalline salt and a cocrystal lies merely in the transfer of a proton. Methods of solvation are generally known in the art. fludrocortisone 5. Solvates and hydrates occur commonly for a large number of pharmaceutical materials. The importance of hydrates/solvates in the pharmaceuticals is enormous because the presence of a particular solvent in the crystal lattice can impart specific properties to the drug substance [2] . Complicating this situation is the fact that crystalline solids (and solvates/hydrates and desolvated/dehydrated solvates/hydrates) can exist in what are known as polymorphs. In this post, we will examine various section of this amended chapter in detail. Therefore, knowledge of three-dimensional structure of the matter is a prerequisite for structure–property correlations and design of functional materials. Weakly basic drugs – strong acid salt 6. material, solvates and hydrates (vide infra) generally have different solubilities. The difference in concentration acts as a driving force towards crystallization (_____) of the stable form. Key Difference – Hydrate vs Anhydrate The two terms “hydrate” and “anhydrate” are two opposite words in their meaning, and the key difference between hydrate and anhydrate is that hydrates are ionic compounds containing free water molecules while anhydrates are compounds that do not contain any free water molecules. The difference in concentration acts as a driving force towards crystallization (_____) of the stable form. Pseudopolymorphs, i.e., co-crystals are also studied along with polymorphism, which are solid crystalline materials comprising two or more molecules or atoms in the same crystal lattice [11]. Active pharmaceutical ingredients (APIs) and excipients may contain solvent (s) in the crystal structure. Alfredo Alternate Cover Vinyl, Pfizer Vs Astrazeneca Difference, Foreflight Turbulence, Stuffed Butternut Squash With Lentils, Massimo Vignelli Facts, Ghirardelli Chocolate Chips Sam's Club, Horizontal Scroll Bar Missing Windows 10, Byu Summer Sports Camps 2021, Places To Visit Victoria, Blue Australian Kelpie, Serta Office Chair Parts, Panko Crusted Salmon With Parmesan, " /> hydrates e.g. The understanding of the physical and chemical properties of different solid forms enables the identification of the most appropriate modification for use in drug development by assessing the risk of form changes under normal and accelerated conditions. There is sometimes a confusion between cocrystals and solvates/hydrates. The main difference between solvate/hydrate and cocrystals is the physical state of the isolated pure components. I can explain the differences in solubility by assuming that the water molecules within the crystal structure of sodium sulfate heptahydrate lower the enthalpy of crystallization, which makes solvation energetically more favorable than the anhydrous salt. hydrates of thiourea (Figuiere et al., 1975; Tomkowiak et al., 2013; Tomkowiak & Katrusiak, 2018) and at pressures above 8 GPa no methane hydrates are formed (Kevenvolden, 1995). Propensity for Solvate/Hydrate Formation U. Griesser, The Importance of Solvates, In: Polymorphism in the Pharmaceutical Industry, R. Hilfiker, ed., Wiley-VCH, Weinheim, 2006, 211-234. Salt form of the drug. Weakly acidic drugs – strong basic salt e.g.barbiturates , sulfonamides. Hydrates are formed from ionic compounds when they exposed … Considering that the synthetic route of STG generates solvates and hydrates , and the dehydration process is an expensive step in industrial scale. If one of the components is liquid and the other is solid, then it is termed as solvates but on the other hand, if both exist in the solid form then they are termed as cocrystals. Exemplary solvates include hydrates, ethanolates, methanolates, isopropanolates and the like. A polymorph screen on a new 1:1 co-crystal of caffeine, C8H10N4O2, with anthranilic acid, C7H7NO2, has revealed a rich diversity of crystal forms (two polymorphs, two hydrates and seven solvates, including two sets of isostructural solvates). Assembly of solvents in the crystal lattice (hydrates, solvates) stoichiometric or non-stoichiometric. Its use is not limited solely to the determination of purity, polymorphs, solvates and hydrates, melting point, and component quantification but also allows the characterization of the surface properties of powders, such as humectants, adsorbents, and surface energy, thus constituting a useful tool in decision making in the case of problems related to the production process. This chapter discusses pseudopolymorphism, and focuses primarily on crystal hydrates. US20130211101A1 US13/781,390 US201313781390A US2013211101A1 US 20130211101 A1 US20130211101 A1 US 20130211101A1 US 201313781390 A US201313781390 A US 201313781390A US 2013211101 A1 US2013211101 A1 US 2013211101A1 Authority US United States Prior art keywords glycopyrrolate tosylate glycopyrrolate tosylate peaks characterize Prior art date 2013-02-28 Solvates and hydrates can be very stable solid forms and may have definite benefits in regard to manufacturing. Hydrates and solvates are thus multicomponent crystalline solid molecular adducts containing both the host molecule (API or excipient) and guest molecule (water (hydrate) or other solvents (solvate)) incorporated in the crystal lattice structure, commonly known as pseudopolymorphic forms. Crystalline solids normally require a significant amount of energy for dissolution due to their highly organized, lattice like structures. Polymorphs, Hydrates and Solvates of a Co-crystal of Caffeine with Anthranilic Acid Nadeesh Madusanka, Mark D. Eddleston, Mihails Arhangelskis and William Jones* Supplementary Material Figure S1 DSC trace (a) and TGA thermogram (b) for Form I of the caffeine:anthranilic acid co-crystal. The solubility tests of these two monohydrates at room temperature (around 23°C) revealed that the difference in aqueous solubility, and thus free energy between these two hydrates, is rather small (110 ± 4 µg/ml and 131 ± 12 µg/ml for hydrates II and I, respectively, ). In addition, the transformation behaviour of solvates during crystallization and storage is often complicated and difficult to understand completely. Polymorphism: Elements can exist in two or more different forms, known as allotropes of that element .eg. This guidance, represents the Food and Drug Administration's (FDA's) current thinking on this topic. A salt with the associated water of crystallization is considered as a hydrate form. 1.2 Crystalline solids: structure and properties 1.2.1 Crystal structure Crystals contain highly ordered arrays of molecules and atoms held together by non-covalent interactions. Hydrates: A wide range of salts form hydrates when dissolved in water. In HG Brittain (ed.) In this review, the fundamental characteristics and trends observed for pharmaceutical hydrates, solvates and amorphous forms are presented, with special emphasis, due to their relative abundance, on pharmaceutical hydrates with single and two-component (i.e. cocrystal) host molecules. 1. Introduction This terminology, Stahly suggests, is descriptive, understandable, and worth keeping. India’s largest k-12 learning app has top-notch teachers from across the nation with excellent teaching skills. A change in solid form is normally evidenced by a discontinuity in the solubility curve, which results from different slope, that is, temperature dependence, of the solubility of the respective forms. What are hydrates? polymorphs, solvates or hydrates. Co-crystals are also generally characterized as hydrates (solvent trapped), solvates (solvent present), and clathrates (molecules trapped) [12]. anhydrous forms of theophyline and ampicillin have higher aqueous solubility than the hydrates. solvate translation in English-French dictionary. These forms have water molecule(s) in the crystalline lattice of the API. hydrates [7] and solvates [8 ]. As moisture is absorbed by a sample, the intermolecular structure and forces within it adapt to accommodate water molecules. The primary difference between solvates and co-crystals is the physical state of the individual components. Part 1. Review of methodology, investigation and prediction of thermodynamic data for sulfur dioxide solvates, MpXq.nSO2, routes to expand the database and forecast of future science and technology. Differences in solid forms often lead to differences in thermodynamic parameters and physicochemical properties for example solubility, dissolution rate, stability and mechanical properties of APIs and excipients. • Drug substance may exist in different solid state forms (polymorphs, solvates, hydrates) • Different physico-chemical properties • Possible effects on dissolution, bioavailability, stability and processability Particle size: Drug substances often milled or micronised … Thus, they are converted to solid forms such as polymorphs, salts, solvates, hydrates, amorphous and co-crystals. The term hydrate is used for crystal structures that contain water molecule (s) in the crystal lattice. Assembly of counter-ions in the crystal lattice proton transfer stoichiometric. Differences between solvates, hydrates and anhydrates/asolvates; Characterisation of solvates and hydrates; Amorphous solids. Material Information Title: Solvates of light metal perchlorates with hydrogen peroxide. This leads to changes in the sample's The present invention relates to 4-[5-Methoxy-6-(2-methyl-6-[l,2,4]triazol-l-yl-pyridin-3- ylamino)-pyrimidin-4-yloxy]-piperidine-l -carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Phase transitions such as polymorph inter-conversion, formation of hydrates, desolvation of solvates, and conversion of the crystalline to amorphous form may occur during various pharmaceutical processes. In addition, the transformation behaviour of solvates during crystallization and storage is often complicated and difficult to understand completely. Thus, the _____ form appears to be more soluble. For example, a working criterion requiring all of the molecular compo-nents to be solids under ambient conditions has been suggested [15,16]. The difference between a crystalline salt and a cocrystal lies merely in the transfer of a proton. Methods of solvation are generally known in the art. fludrocortisone 5. Solvates and hydrates occur commonly for a large number of pharmaceutical materials. The importance of hydrates/solvates in the pharmaceuticals is enormous because the presence of a particular solvent in the crystal lattice can impart specific properties to the drug substance [2] . Complicating this situation is the fact that crystalline solids (and solvates/hydrates and desolvated/dehydrated solvates/hydrates) can exist in what are known as polymorphs. In this post, we will examine various section of this amended chapter in detail. Therefore, knowledge of three-dimensional structure of the matter is a prerequisite for structure–property correlations and design of functional materials. Weakly basic drugs – strong acid salt 6. material, solvates and hydrates (vide infra) generally have different solubilities. The difference in concentration acts as a driving force towards crystallization (_____) of the stable form. Key Difference – Hydrate vs Anhydrate The two terms “hydrate” and “anhydrate” are two opposite words in their meaning, and the key difference between hydrate and anhydrate is that hydrates are ionic compounds containing free water molecules while anhydrates are compounds that do not contain any free water molecules. The difference in concentration acts as a driving force towards crystallization (_____) of the stable form. Pseudopolymorphs, i.e., co-crystals are also studied along with polymorphism, which are solid crystalline materials comprising two or more molecules or atoms in the same crystal lattice [11]. Active pharmaceutical ingredients (APIs) and excipients may contain solvent (s) in the crystal structure. Alfredo Alternate Cover Vinyl, Pfizer Vs Astrazeneca Difference, Foreflight Turbulence, Stuffed Butternut Squash With Lentils, Massimo Vignelli Facts, Ghirardelli Chocolate Chips Sam's Club, Horizontal Scroll Bar Missing Windows 10, Byu Summer Sports Camps 2021, Places To Visit Victoria, Blue Australian Kelpie, Serta Office Chair Parts, Panko Crusted Salmon With Parmesan, " /> hydrates e.g. The understanding of the physical and chemical properties of different solid forms enables the identification of the most appropriate modification for use in drug development by assessing the risk of form changes under normal and accelerated conditions. There is sometimes a confusion between cocrystals and solvates/hydrates. The main difference between solvate/hydrate and cocrystals is the physical state of the isolated pure components. I can explain the differences in solubility by assuming that the water molecules within the crystal structure of sodium sulfate heptahydrate lower the enthalpy of crystallization, which makes solvation energetically more favorable than the anhydrous salt. hydrates of thiourea (Figuiere et al., 1975; Tomkowiak et al., 2013; Tomkowiak & Katrusiak, 2018) and at pressures above 8 GPa no methane hydrates are formed (Kevenvolden, 1995). Propensity for Solvate/Hydrate Formation U. Griesser, The Importance of Solvates, In: Polymorphism in the Pharmaceutical Industry, R. Hilfiker, ed., Wiley-VCH, Weinheim, 2006, 211-234. Salt form of the drug. Weakly acidic drugs – strong basic salt e.g.barbiturates , sulfonamides. Hydrates are formed from ionic compounds when they exposed … Considering that the synthetic route of STG generates solvates and hydrates , and the dehydration process is an expensive step in industrial scale. If one of the components is liquid and the other is solid, then it is termed as solvates but on the other hand, if both exist in the solid form then they are termed as cocrystals. Exemplary solvates include hydrates, ethanolates, methanolates, isopropanolates and the like. A polymorph screen on a new 1:1 co-crystal of caffeine, C8H10N4O2, with anthranilic acid, C7H7NO2, has revealed a rich diversity of crystal forms (two polymorphs, two hydrates and seven solvates, including two sets of isostructural solvates). Assembly of solvents in the crystal lattice (hydrates, solvates) stoichiometric or non-stoichiometric. Its use is not limited solely to the determination of purity, polymorphs, solvates and hydrates, melting point, and component quantification but also allows the characterization of the surface properties of powders, such as humectants, adsorbents, and surface energy, thus constituting a useful tool in decision making in the case of problems related to the production process. This chapter discusses pseudopolymorphism, and focuses primarily on crystal hydrates. US20130211101A1 US13/781,390 US201313781390A US2013211101A1 US 20130211101 A1 US20130211101 A1 US 20130211101A1 US 201313781390 A US201313781390 A US 201313781390A US 2013211101 A1 US2013211101 A1 US 2013211101A1 Authority US United States Prior art keywords glycopyrrolate tosylate glycopyrrolate tosylate peaks characterize Prior art date 2013-02-28 Solvates and hydrates can be very stable solid forms and may have definite benefits in regard to manufacturing. Hydrates and solvates are thus multicomponent crystalline solid molecular adducts containing both the host molecule (API or excipient) and guest molecule (water (hydrate) or other solvents (solvate)) incorporated in the crystal lattice structure, commonly known as pseudopolymorphic forms. Crystalline solids normally require a significant amount of energy for dissolution due to their highly organized, lattice like structures. Polymorphs, Hydrates and Solvates of a Co-crystal of Caffeine with Anthranilic Acid Nadeesh Madusanka, Mark D. Eddleston, Mihails Arhangelskis and William Jones* Supplementary Material Figure S1 DSC trace (a) and TGA thermogram (b) for Form I of the caffeine:anthranilic acid co-crystal. The solubility tests of these two monohydrates at room temperature (around 23°C) revealed that the difference in aqueous solubility, and thus free energy between these two hydrates, is rather small (110 ± 4 µg/ml and 131 ± 12 µg/ml for hydrates II and I, respectively, ). In addition, the transformation behaviour of solvates during crystallization and storage is often complicated and difficult to understand completely. Polymorphism: Elements can exist in two or more different forms, known as allotropes of that element .eg. This guidance, represents the Food and Drug Administration's (FDA's) current thinking on this topic. A salt with the associated water of crystallization is considered as a hydrate form. 1.2 Crystalline solids: structure and properties 1.2.1 Crystal structure Crystals contain highly ordered arrays of molecules and atoms held together by non-covalent interactions. Hydrates: A wide range of salts form hydrates when dissolved in water. In HG Brittain (ed.) In this review, the fundamental characteristics and trends observed for pharmaceutical hydrates, solvates and amorphous forms are presented, with special emphasis, due to their relative abundance, on pharmaceutical hydrates with single and two-component (i.e. cocrystal) host molecules. 1. Introduction This terminology, Stahly suggests, is descriptive, understandable, and worth keeping. India’s largest k-12 learning app has top-notch teachers from across the nation with excellent teaching skills. A change in solid form is normally evidenced by a discontinuity in the solubility curve, which results from different slope, that is, temperature dependence, of the solubility of the respective forms. What are hydrates? polymorphs, solvates or hydrates. Co-crystals are also generally characterized as hydrates (solvent trapped), solvates (solvent present), and clathrates (molecules trapped) [12]. anhydrous forms of theophyline and ampicillin have higher aqueous solubility than the hydrates. solvate translation in English-French dictionary. These forms have water molecule(s) in the crystalline lattice of the API. hydrates [7] and solvates [8 ]. As moisture is absorbed by a sample, the intermolecular structure and forces within it adapt to accommodate water molecules. The primary difference between solvates and co-crystals is the physical state of the individual components. Part 1. Review of methodology, investigation and prediction of thermodynamic data for sulfur dioxide solvates, MpXq.nSO2, routes to expand the database and forecast of future science and technology. Differences in solid forms often lead to differences in thermodynamic parameters and physicochemical properties for example solubility, dissolution rate, stability and mechanical properties of APIs and excipients. • Drug substance may exist in different solid state forms (polymorphs, solvates, hydrates) • Different physico-chemical properties • Possible effects on dissolution, bioavailability, stability and processability Particle size: Drug substances often milled or micronised … Thus, they are converted to solid forms such as polymorphs, salts, solvates, hydrates, amorphous and co-crystals. The term hydrate is used for crystal structures that contain water molecule (s) in the crystal lattice. Assembly of counter-ions in the crystal lattice proton transfer stoichiometric. Differences between solvates, hydrates and anhydrates/asolvates; Characterisation of solvates and hydrates; Amorphous solids. Material Information Title: Solvates of light metal perchlorates with hydrogen peroxide. This leads to changes in the sample's The present invention relates to 4-[5-Methoxy-6-(2-methyl-6-[l,2,4]triazol-l-yl-pyridin-3- ylamino)-pyrimidin-4-yloxy]-piperidine-l -carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Phase transitions such as polymorph inter-conversion, formation of hydrates, desolvation of solvates, and conversion of the crystalline to amorphous form may occur during various pharmaceutical processes. In addition, the transformation behaviour of solvates during crystallization and storage is often complicated and difficult to understand completely. Thus, the _____ form appears to be more soluble. For example, a working criterion requiring all of the molecular compo-nents to be solids under ambient conditions has been suggested [15,16]. The difference between a crystalline salt and a cocrystal lies merely in the transfer of a proton. Methods of solvation are generally known in the art. fludrocortisone 5. Solvates and hydrates occur commonly for a large number of pharmaceutical materials. The importance of hydrates/solvates in the pharmaceuticals is enormous because the presence of a particular solvent in the crystal lattice can impart specific properties to the drug substance [2] . Complicating this situation is the fact that crystalline solids (and solvates/hydrates and desolvated/dehydrated solvates/hydrates) can exist in what are known as polymorphs. In this post, we will examine various section of this amended chapter in detail. Therefore, knowledge of three-dimensional structure of the matter is a prerequisite for structure–property correlations and design of functional materials. Weakly basic drugs – strong acid salt 6. material, solvates and hydrates (vide infra) generally have different solubilities. The difference in concentration acts as a driving force towards crystallization (_____) of the stable form. Key Difference – Hydrate vs Anhydrate The two terms “hydrate” and “anhydrate” are two opposite words in their meaning, and the key difference between hydrate and anhydrate is that hydrates are ionic compounds containing free water molecules while anhydrates are compounds that do not contain any free water molecules. The difference in concentration acts as a driving force towards crystallization (_____) of the stable form. Pseudopolymorphs, i.e., co-crystals are also studied along with polymorphism, which are solid crystalline materials comprising two or more molecules or atoms in the same crystal lattice [11]. Active pharmaceutical ingredients (APIs) and excipients may contain solvent (s) in the crystal structure. Alfredo Alternate Cover Vinyl, Pfizer Vs Astrazeneca Difference, Foreflight Turbulence, Stuffed Butternut Squash With Lentils, Massimo Vignelli Facts, Ghirardelli Chocolate Chips Sam's Club, Horizontal Scroll Bar Missing Windows 10, Byu Summer Sports Camps 2021, Places To Visit Victoria, Blue Australian Kelpie, Serta Office Chair Parts, Panko Crusted Salmon With Parmesan, " />
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solvates and hydrates difference

When combining API to counterions or coformers (in many cases the counterions and coformers are the same compounds), a salt or a cocrystal can be prepared. The theoretical parameters underlying the selection of coformers and screening of cocrystals have been summarized and different methods of cocrystal formation vibrational spectroscopy. These differences in physical properties make The present invention relates to 4-[5-Methoxy-6-(2-methyl-6-[l,2,4]triazol-l-yl-pyridin-3- ylamino)-pyrimidin-4-yloxy]-piperidine-l -carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Donald Jenkins. Solvates. The reason solvates and hydrates are not polymorphisms is because they make the solid molecule _____ different. Many a times an API cannot be formulated in its pure form due to various issues of instability, solubility, compatibility, dissolution, etc. Solid Forms (Solvates/Hydrates)Solvates / Hydrates Molecular adducts that incorporate solvent molecules in their crystal lattices; Solvent is water Hydrates Solvent is other solvents Solvates Non-solvated SolvatePharmaceutical Solid Form Screening, Characterization, and Selection 8Enhancing Drug Bioavailability and Solubility, Boston, MA, Jan. 25 - 26, 2012 The Thermodynamic Solvate Difference Rule: Solvation Parameters and Their Use in Interpretation of the Role of Bound Solvent in Condensed-Phase Solvates. Methods of analyzing the solid state. Next: Differentiate between the terms isomers and polymers. ... solvates or hydrates. Pharmaceutical hydrates are viable forms for drug products because there is no safety concern about water as a crystal adduct. Thus, considering the slight difference between STG and STGA, the most suitable form for pharmaceutical purposes and … The formation of organic solvates instead of hydrates plays a significant role since the pharmaceutical substances are often exposed to organic solvent during production and processing. crystals such as hydrates, solvates and co-crystals, which consist of more than one type of type of molecule. Solids can exist as crystalline, amorphous, solvate (hydrate), and desolvated (dehydrated) forms. 1.2 Crystalline solids – structure and properties 1.2.1 Crystal structure Crystals contain highly ordered arrays of molecules and atoms held together by non-covalent interac-tions. We can consider as a simple example the unit cell of an inorganic salt, sodium chloride. Abstract Solvates and hydrates occur commonly for a large number of pharmaceutical materials. Solid form patents and patentability Entrenched terms include salts, hydrates, and solvates, in which one of the components is clearly an ion, water, or solvent molecule, respectively. The utilization of the most physically stable crystalline form is typically desired as any change in solid form may affect the bioavailability associated with a drug product.3 Pharmaceutical scientists usually search for a solid form with the best properties f… hydrate. The Canadian Patent Office (CPO) is seeking comments on its proposed revisions to Chapter 17 of the Manual of Patent Office Practice (MOPOP) as it relates to pharmaceutical solid forms (namely, polymorphs, salts, hydrates, solvates, desolvates and co-crystals). Today, almost every patent shows DSC and TG curves. Crystal form (cocrystals, polymorphs, salts, hydrates and solvates) diversity is and will continue to be a contentious issue for the pharmaceutical industry. Lipophilicity of the drug . Many hydrates will dehydrate formation of hydrates/solvates of pharmaceutical materials is the combined use of DVS with . Stable polymorphic forms of dapagliflozin can be crystallized as solvates of the present invention. 7. pKa of the drug & pH . Solvates and hydrates provide a way of in-creasing the number of related solid forms for a … the different hydrates/solvates, assuming that the solvate was formed only by the crystallization solvent. 27 § Lattice energy is the energy difference between the molecules in the lattice and when infinitely separated in their most stable conformation. Figure 1.2 shows the ordered arrangement of Cl− ions and Na+ ions that make… Furthermore, an added advantage with the solvates is that they offer an alternative route to control polymorphism through desolvation [3–5] . ethanol solvate, form E and two methanol solvates, tentatively designated as forms M2 and M3, having in mind that one of them may actually correspond to the known methanol solvate, earlier marked as form M1), as well as previously known 4.5-hydrate of catechin (H1), was confirmed via 13C CPMAS NMR spectroscopy (Figure S1). A solvate is a compound containing one water of crystallization e.g (Cr (NH3)4 (OH2)Cl)Cl2 while a hydrate is a compound that has several waters of coordination e.g (Cr (OH2)6)Cl3. Co-crystals. Hydrate or Anhydrate? There are many examples of drugs that are formulated as a hydrate form, such as cephalexin, cefaclor, ampicillin and theophylline. Definition of solvate. (Entry 1 of 2) : an aggregate that consists of a solute ion or molecule with one or more solvent molecules also : a substance (such as a hydrate) containing such ions. solvate. verb. solvated; solvating. Hydrates are of particular interest among solid APIs solvates for several reasons. 120 Solvates, which have the same overall crystal packing, but 121 differ only in the solvents included in their crystal structures, are termed isostructural or 122 isomorphous solvates, e.g. Donald Jenkins. Stable polymorphic forms of dapagliflozin can be crystallized as solvates of the present invention. There have been efforts in the literature to focus or at least narrow the scope of co-crystal research. Differences between cocrystals with salts, solvates and hydrates are summarized along with the advantages of cocrystals with examples. The difference between a crystalline salt and a cocrystal lies merely in the transfer of a proton. Solvates and hydrates occur commonly for a large number of pharmaceutical materials. Solvated organic compounds contain a solvent of crystallization other than water. Analysis of difference spectra of the Raman data for solids obtained from slow cooling of ... solutions were 2.5 hydrates; this formation of different hydrates were supported by the Raman difference analysis. ANDAs: Pharmaceutical Solid Polymorphism Chemistry, Manufacturing, and Controls Information . includes solvates, hydrates, and both stoichiometric and non-stoichiometric lattice inclusion compounds. Leslie Glasser. Theophylline, Ampicillin Organic solvates > non solvates e.g. In this guide, we give a complete explanation of hydrates, including the hydrate definition, the three different types of hydrates, the rules you need to know to name hydrates and write out their formulas, and common hydrate examples you may have heard of. 1. Polymorphs and hydrates differ in internal solid-state structure and therefore, possess different physical properties, including melting point, crystal habit, colour, density, compressibility, packing, thermodynamic, spectroscopic, kinetic, interfacial, and flow properties1. Cocrystals, hydrates and solvates are held together by weak interactions that are in most cases broken upon dissolution. When a drug substance exists in polymorphic forms, it is said to exhibit polymorphism. Properties of a matter are intrinsically dependent on the internal arrangement of molecules in the solid state. The liquid water can then be evaporated to leave the solid hydrate. A method of treating or preventing a clinical symptom of ocular allergy, comprising administering to the eye of a patient an effective amount of alcaftadine, its pharmaceutically acceptable salts, its N-oxides, hydrates, solvates, polymorphs, pro-drugs, or … 15 The compounds which are liquid at room temperature are called as solvates whereas those compounds which are solid at room temperature are called as cocrystals. A change in solid form is normally evidenced by a discontinuity in the solubility curve, which results from different slope, that is, temperature dependence, of the solubility of the respective forms. Assembly of non-ionised co-formers (solids) in the crystal lattice stoichiometric Hence, with respect to oral administration, dissolution of such different forms of a drug substance in the stomach or the intestinal canal will lead Pharmaceutical hydrates are viable forms for drug products because there is no safety concern about water as a crystal adduct. First, the unique character of the water molecule—its relatively small size and the possibility to form the interactions as both a donor and acceptor of H-bonding, sometimes simultaneously, make it an important “building material” in the field of crystal engineering. in-situ. Crystalline solids normally require a significant amount of energy for dissolution due to their highly organized, lattice like structures. If one component is a liquid at room temperature, the crystals are designated as solvates or hydrates. If one of the components is liquid and the other is solid, then it is termed as solvates but on the other hand, if both exist in the solid form then they are termed as cocrystals. ... "Methods for the characterization of polymorphs and solvates." ‡ Stoichiometric hydrates (solvates) are regarded as molecular compounds and contain a fixed solvent ∶ compound ratio, in contrast to non-stoichiometric solvates, a type of inclusion compounds. Properties of solvates / hydrates (i) Generally, the anhydrous form of a drug has greater aqueous solubility than its hydrates. e.g. solvates, hydrates, salts5,6,7. Crystal Desolvated Solvate/Dehydrated Hydrate Although hydrates can have benefits in manufactur-ing, they can also present a significant problem from the standpoint of drying. This 2½ day course aims to give chemists and chemical engineers a thorough practical knowledge of crystallisation processes. 113 114 Occasionally, a compound of a given hydration/solvation composition may crystallize into 115 more than one crystalline form; an example of such a compound is nitrofurantoin (5). Water and other solvent molecules often form H bonds and coordi- hydrate and solvate forms can be utilized to alter the rate of drug release or to stabilize the formulation. Solvates and hydrates can be very stable solid forms and may have definite benefits in regard to manufacturing. Analytical methods; Infra-red, Raman; XRPD; DSC; Patent and Regulatory Issues. a compound formed by solvation (the combination of solvent molecules with molecules or ions of the solute) Crystals containing an active pharmaceutical ingredient as the "host" and something other than a solvent or water as the "guest" are increasingly being referred to as cocrystals. This is the same situation as with salts. Hydrate forms of APIs are quite common; it is estimated that approximately one-third of APIs can form hydrates if exposed to the conditions that are conducive for hydrate formation [20]. When the solvent is water, they are called hydrates, and are viable forms for drug products, as there are no safety concerns surrounding water as a crystal adduct. Co-crystal Versus Solvates: 2, 3, 4 The only difference between solvates and cocrystals is the physical state of the components. Due to variation in the use of the term, structures such as solvates and clathrates may or may not be considered cocrystals in a given situation. The existence of different crystalline forms (polymorphs, hydrates, and solvates) represents one of the most challenging phenomena in solid-state chemistry and related sciences, since we are still not able to predict the number of practically relevant forms and the conditions under which these can be grown or exist. 8. For example, ferrous chloride FeCl 2 forms the hydrate FeCl 2 (H 2 O) 4. Hydrates can be classified as three categories based on different structural aspects: Class I represents hydrates where the water molecules exist at isolated sites; Class II hydrates … In pharmaceuticals HSM is used to support differential scanning calorimetry (DSC) and thermo-gravimetric analysis (TGA) observations and to … 116 Nitrofurantoin can be crystallized as two monohydrate forms (Forms I … If only the amorphous phase hydrates/solvates upon exposure to the appropriate vapour, then the amorphous content of a partially amorphous material can be determined. hydrate and isopropanolate of hexakis(2,3,6-tri-O-acetyl)-α-123 cyclodextrin (6). Solvates and hydrates can be very stable solid forms and may have definite benefits in regard to manufacturing. This is because the hydrates are already in equilibrium with water and therefore have less demand for water. WANJALA002 answered the question on May 20, 2018 at 12:35. A polymorph screen on a new 1:1 co-crystal of caffeine, C8H10N4O2, with anthranilic acid, C7H7NO2, has revealed a rich diversity of crystal forms (two polymorphs, two hydrates and seven solvates, including two sets of isostructural solvates). In this classification scheme, for example, solvates and hydrates are types of cocrystals. The Journal of Chemical Thermodynamics 2019, 135 , 278-286. Salts. Pharmaceutical solvates, hydrates and amorphous forms: ... and the degree of disorder, affecting the entropy. the same overall crystal packing. 2. Results and Discussion It has been reported that olanzapine exists in two anhydrous forms which are clearly distinguishable by X-ray powder diffractometry: one of them, defined as anhydrous olanzapine form II, was not well In the pharmaceutical environment, these crystalline subphases consist of (at least) two different molecules, one is the API and the other is an organic solvent (in the case of a solvate), … Presently, we have established that the porous crystals of ZnAsp 2 nH 2 O display structural features connected to … Materials and Methods . Leslie Glasser. The formation of organic solvates instead of hydrates plays a significant role since the pharmaceutical substances are often exposed to organic solvent during production and processing. The Thermodynamic Difference Rule (TDR) for non-aqueous solvates. We can consider as a simple example the unit U. Griesser, The Importance of Solvates, In: Polymorphism in the Pharmaceutical Industry, R. Hilfiker, ed., Wiley-VCH, Weinheim, 2006, 211-234. This chapter discusses pseudopolymorphism, and focuses primarily on crystal hydrates. During crystallisation, some compounds may entrap solvent molecule in the crystal lattice (calledcrystal Co-crystal Versus Solvates: 2, 3, 4 The only difference between solvates and cocrystals is the physical state of the components. 4-5 Hydrates (water solvates) are of special divided further into polymorphs, solvates, hydrates and co-crystals (Cui, 2007:6). Pharmaceutical hydrates are more common than other organic solvates due to the atmospheric humidity, the small size of water molecules, and the ability of water to act as hydrogen donor as well as acceptor. The transfer of protons from one component to another in a crystal is dependent on the environment. What is claimed is 1. Solvate definition is - an aggregate that consists of a solute ion or molecule with one or more solvent molecules; also : a substance (such as a hydrate) containing such ions. Introduction. The transfer of protons from one component to another in a crystal is dependent on the environment. Thus, polymorphs and solvates are obtained from various solvent-based techniques. Download PDF. Improving the solubility of BCS Thus, the _____ form appears to be more soluble. Solvates and hydrates. Such forms can be further screened for polymorphs and solvates/hydrates. This could change the dissolution rate and transport characteristics of the drug. 1 . The reason solvates and hydrates are not polymorphisms is because they make the solid molecule _____ different. Inorganic Chemistry, 2007. the crystal forms of a compound that differ in the species or stoichiometry of the included solvent molecules, are If you're studying chemistry, you probably need to know what a hydrate is and the role it serves. HSM is rapidly gaining interest in pharmaceuticals as well as in other fields as a regular characterization technique. components. 112 “solvates” and “hydrates”. More active ingredients are polyphasic systems, which may appear concomitantly in the manufacturing procedure of the active ingredients. If the solvates contain water as a solvent in their crystal lattice then they are known as hydrates. Figure 1.1 Classification of solids. These are known as solvates. Pseudopolymorphism (Hydrates / Solvates ) Anhydrates > hydrates e.g. The understanding of the physical and chemical properties of different solid forms enables the identification of the most appropriate modification for use in drug development by assessing the risk of form changes under normal and accelerated conditions. There is sometimes a confusion between cocrystals and solvates/hydrates. The main difference between solvate/hydrate and cocrystals is the physical state of the isolated pure components. I can explain the differences in solubility by assuming that the water molecules within the crystal structure of sodium sulfate heptahydrate lower the enthalpy of crystallization, which makes solvation energetically more favorable than the anhydrous salt. hydrates of thiourea (Figuiere et al., 1975; Tomkowiak et al., 2013; Tomkowiak & Katrusiak, 2018) and at pressures above 8 GPa no methane hydrates are formed (Kevenvolden, 1995). Propensity for Solvate/Hydrate Formation U. Griesser, The Importance of Solvates, In: Polymorphism in the Pharmaceutical Industry, R. Hilfiker, ed., Wiley-VCH, Weinheim, 2006, 211-234. Salt form of the drug. Weakly acidic drugs – strong basic salt e.g.barbiturates , sulfonamides. Hydrates are formed from ionic compounds when they exposed … Considering that the synthetic route of STG generates solvates and hydrates , and the dehydration process is an expensive step in industrial scale. If one of the components is liquid and the other is solid, then it is termed as solvates but on the other hand, if both exist in the solid form then they are termed as cocrystals. Exemplary solvates include hydrates, ethanolates, methanolates, isopropanolates and the like. A polymorph screen on a new 1:1 co-crystal of caffeine, C8H10N4O2, with anthranilic acid, C7H7NO2, has revealed a rich diversity of crystal forms (two polymorphs, two hydrates and seven solvates, including two sets of isostructural solvates). Assembly of solvents in the crystal lattice (hydrates, solvates) stoichiometric or non-stoichiometric. Its use is not limited solely to the determination of purity, polymorphs, solvates and hydrates, melting point, and component quantification but also allows the characterization of the surface properties of powders, such as humectants, adsorbents, and surface energy, thus constituting a useful tool in decision making in the case of problems related to the production process. This chapter discusses pseudopolymorphism, and focuses primarily on crystal hydrates. US20130211101A1 US13/781,390 US201313781390A US2013211101A1 US 20130211101 A1 US20130211101 A1 US 20130211101A1 US 201313781390 A US201313781390 A US 201313781390A US 2013211101 A1 US2013211101 A1 US 2013211101A1 Authority US United States Prior art keywords glycopyrrolate tosylate glycopyrrolate tosylate peaks characterize Prior art date 2013-02-28 Solvates and hydrates can be very stable solid forms and may have definite benefits in regard to manufacturing. Hydrates and solvates are thus multicomponent crystalline solid molecular adducts containing both the host molecule (API or excipient) and guest molecule (water (hydrate) or other solvents (solvate)) incorporated in the crystal lattice structure, commonly known as pseudopolymorphic forms. Crystalline solids normally require a significant amount of energy for dissolution due to their highly organized, lattice like structures. Polymorphs, Hydrates and Solvates of a Co-crystal of Caffeine with Anthranilic Acid Nadeesh Madusanka, Mark D. Eddleston, Mihails Arhangelskis and William Jones* Supplementary Material Figure S1 DSC trace (a) and TGA thermogram (b) for Form I of the caffeine:anthranilic acid co-crystal. The solubility tests of these two monohydrates at room temperature (around 23°C) revealed that the difference in aqueous solubility, and thus free energy between these two hydrates, is rather small (110 ± 4 µg/ml and 131 ± 12 µg/ml for hydrates II and I, respectively, ). In addition, the transformation behaviour of solvates during crystallization and storage is often complicated and difficult to understand completely. Polymorphism: Elements can exist in two or more different forms, known as allotropes of that element .eg. This guidance, represents the Food and Drug Administration's (FDA's) current thinking on this topic. A salt with the associated water of crystallization is considered as a hydrate form. 1.2 Crystalline solids: structure and properties 1.2.1 Crystal structure Crystals contain highly ordered arrays of molecules and atoms held together by non-covalent interactions. Hydrates: A wide range of salts form hydrates when dissolved in water. In HG Brittain (ed.) In this review, the fundamental characteristics and trends observed for pharmaceutical hydrates, solvates and amorphous forms are presented, with special emphasis, due to their relative abundance, on pharmaceutical hydrates with single and two-component (i.e. cocrystal) host molecules. 1. Introduction This terminology, Stahly suggests, is descriptive, understandable, and worth keeping. India’s largest k-12 learning app has top-notch teachers from across the nation with excellent teaching skills. A change in solid form is normally evidenced by a discontinuity in the solubility curve, which results from different slope, that is, temperature dependence, of the solubility of the respective forms. What are hydrates? polymorphs, solvates or hydrates. Co-crystals are also generally characterized as hydrates (solvent trapped), solvates (solvent present), and clathrates (molecules trapped) [12]. anhydrous forms of theophyline and ampicillin have higher aqueous solubility than the hydrates. solvate translation in English-French dictionary. These forms have water molecule(s) in the crystalline lattice of the API. hydrates [7] and solvates [8 ]. As moisture is absorbed by a sample, the intermolecular structure and forces within it adapt to accommodate water molecules. The primary difference between solvates and co-crystals is the physical state of the individual components. Part 1. Review of methodology, investigation and prediction of thermodynamic data for sulfur dioxide solvates, MpXq.nSO2, routes to expand the database and forecast of future science and technology. Differences in solid forms often lead to differences in thermodynamic parameters and physicochemical properties for example solubility, dissolution rate, stability and mechanical properties of APIs and excipients. • Drug substance may exist in different solid state forms (polymorphs, solvates, hydrates) • Different physico-chemical properties • Possible effects on dissolution, bioavailability, stability and processability Particle size: Drug substances often milled or micronised … Thus, they are converted to solid forms such as polymorphs, salts, solvates, hydrates, amorphous and co-crystals. The term hydrate is used for crystal structures that contain water molecule (s) in the crystal lattice. Assembly of counter-ions in the crystal lattice proton transfer stoichiometric. Differences between solvates, hydrates and anhydrates/asolvates; Characterisation of solvates and hydrates; Amorphous solids. Material Information Title: Solvates of light metal perchlorates with hydrogen peroxide. This leads to changes in the sample's The present invention relates to 4-[5-Methoxy-6-(2-methyl-6-[l,2,4]triazol-l-yl-pyridin-3- ylamino)-pyrimidin-4-yloxy]-piperidine-l -carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Phase transitions such as polymorph inter-conversion, formation of hydrates, desolvation of solvates, and conversion of the crystalline to amorphous form may occur during various pharmaceutical processes. In addition, the transformation behaviour of solvates during crystallization and storage is often complicated and difficult to understand completely. Thus, the _____ form appears to be more soluble. For example, a working criterion requiring all of the molecular compo-nents to be solids under ambient conditions has been suggested [15,16]. The difference between a crystalline salt and a cocrystal lies merely in the transfer of a proton. Methods of solvation are generally known in the art. fludrocortisone 5. Solvates and hydrates occur commonly for a large number of pharmaceutical materials. The importance of hydrates/solvates in the pharmaceuticals is enormous because the presence of a particular solvent in the crystal lattice can impart specific properties to the drug substance [2] . Complicating this situation is the fact that crystalline solids (and solvates/hydrates and desolvated/dehydrated solvates/hydrates) can exist in what are known as polymorphs. In this post, we will examine various section of this amended chapter in detail. Therefore, knowledge of three-dimensional structure of the matter is a prerequisite for structure–property correlations and design of functional materials. Weakly basic drugs – strong acid salt 6. material, solvates and hydrates (vide infra) generally have different solubilities. The difference in concentration acts as a driving force towards crystallization (_____) of the stable form. Key Difference – Hydrate vs Anhydrate The two terms “hydrate” and “anhydrate” are two opposite words in their meaning, and the key difference between hydrate and anhydrate is that hydrates are ionic compounds containing free water molecules while anhydrates are compounds that do not contain any free water molecules. The difference in concentration acts as a driving force towards crystallization (_____) of the stable form. Pseudopolymorphs, i.e., co-crystals are also studied along with polymorphism, which are solid crystalline materials comprising two or more molecules or atoms in the same crystal lattice [11]. Active pharmaceutical ingredients (APIs) and excipients may contain solvent (s) in the crystal structure.

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Annak érdekében, hogy akár hétvégén vagy éjszaka is megfelelő védelemhez juthasson, telefonos ügyeletet tartok, melynek keretében bármikor hívhat, ha segítségre van szüksége.

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Büntetőjog

Amennyiben Önt letartóztatják, előállítják, akkor egy meggondolatlan mondat vagy ésszerűtlen döntés később az eljárás folyamán óriási hátrányt okozhat Önnek.

Tapasztalatom szerint már a kihallgatás első percei is óriási pszichikai nyomást jelentenek a terhelt számára, pedig a „tiszta fejre” és meggondolt viselkedésre ilyenkor óriási szükség van. Ez az a helyzet, ahol Ön nem hibázhat, nem kockáztathat, nagyon fontos, hogy már elsőre jól döntsön!

Védőként én nem csupán segítek Önnek az eljárás folyamán az eljárási cselekmények elvégzésében (beadvány szerkesztés, jelenlét a kihallgatásokon stb.) hanem egy kézben tartva mérem fel lehetőségeit, kidolgozom védelmének precíz stratégiáit, majd ennek alapján határozom meg azt az eszközrendszert, amellyel végig képviselhetem Önt és eredményül elérhetem, hogy semmiképp ne érje indokolatlan hátrány a büntetőeljárás következményeként.

Védőügyvédjeként én nem csupán bástyaként védem érdekeit a hatóságokkal szemben és dolgozom védelmének stratégiáján, hanem nagy hangsúlyt fektetek az Ön folyamatos tájékoztatására, egyben enyhítve esetleges kilátástalannak tűnő helyzetét is.

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Jogi tanácsadás, ügyintézés. Peren kívüli megegyezések teljes körű lebonyolítása. Megállapodások, szerződések és az ezekhez kapcsolódó dokumentációk megszerkesztése, ellenjegyzése. Bíróságok és más hatóságok előtti teljes körű jogi képviselet különösen az alábbi területeken:

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Ingatlanjog

Ingatlan tulajdonjogának átruházáshoz kapcsolódó szerződések (adásvétel, ajándékozás, csere, stb.) elkészítése és ügyvédi ellenjegyzése, valamint teljes körű jogi tanácsadás és földhivatal és adóhatóság előtti jogi képviselet.

Bérleti szerződések szerkesztése és ellenjegyzése.

Ingatlan átminősítése során jogi képviselet ellátása.

Közös tulajdonú ingatlanokkal kapcsolatos ügyek, jogviták, valamint a közös tulajdon megszüntetésével kapcsolatos ügyekben való jogi képviselet ellátása.

Társasház alapítása, alapító okiratok megszerkesztése, társasházak állandó és eseti jogi képviselete, jogi tanácsadás.

Ingatlanokhoz kapcsolódó haszonélvezeti-, használati-, szolgalmi jog alapítása vagy megszüntetése során jogi képviselet ellátása, ezekkel kapcsolatos okiratok szerkesztése.

Ingatlanokkal kapcsolatos birtokviták, valamint elbirtoklási ügyekben való ügyvédi képviselet.

Az illetékes földhivatalok előtti teljes körű képviselet és ügyintézés.

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Társasági jog

Cégalapítási és változásbejegyzési eljárásban, továbbá végelszámolási eljárásban teljes körű jogi képviselet ellátása, okiratok szerkesztése és ellenjegyzése

Tulajdonrész, illetve üzletrész adásvételi szerződések megszerkesztése és ügyvédi ellenjegyzése.

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Állandó, komplex képviselet

Még mindig él a cégvezetőkben az a tévképzet, hogy ügyvédet választani egy vállalkozás vagy társaság számára elegendő akkor, ha bíróságra kell menni.

Semmivel sem árthat annyit cége nehezen elért sikereinek, mint, ha megfelelő jogi képviselet nélkül hagyná vállalatát!

Irodámban egyedi megállapodás alapján lehetőség van állandó megbízás megkötésére, melynek keretében folyamatosan együtt tudunk működni, bármilyen felmerülő kérdés probléma esetén kereshet személyesen vagy telefonon is.  Ennek nem csupán az az előnye, hogy Ön állandó ügyfelemként előnyt élvez majd időpont-egyeztetéskor, hanem ennél sokkal fontosabb, hogy az Ön cégét megismerve személyesen kezeskedem arról, hogy tevékenysége folyamatosan a törvényesség talaján maradjon. Megismerve az Ön cégének munkafolyamatait és folyamatosan együttműködve vezetőséggel a jogi tudást igénylő helyzeteket nem csupán utólag tudjuk kezelni, akkor, amikor már „ég a ház”, hanem előre felkészülve gondoskodhatunk arról, hogy Önt ne érhesse meglepetés.

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